My experience is very typical. . So it was both obvious and convincing the difference between the groups to the workers and the track management. If you are experiencing any odd adverse reactions, youll need to consult with your doctor ASAP. I think we did rigorous reviews of proposals for research.. How covid-19 conspiracy videos keep getting millions of views. He is the inventor of the optical mouse and one of the first Internet search engines, Infoseek. Telling the truth, he tweeted. ICER Publishes Final Evidence Report and Policy Recommendations on Outpatient Treatments for COVID-19 - ICER. Here are the key things you should know about fluvoxamine for COVID: It works. I couldnt tell I was on the drug. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. [NIH] doesnt want any of these treatments. Is that really true? It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. 90,000 Americans will die from COVID in just the next 3 weeks, a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die, Lenze fluvoxamine RCT that was published in JAMA. Fluvoxamine public data repository: The fluvoxamine public repository has all the documents related to fluvoxamine for COVID, including the RCT, RWE, observational studies and a link to the 1 hour lecture on serotonin and fluvoxamine. His appearance on an episode of anti-covid-vaccine, pro-ivermectin pundit Bret Weinsteins DarkHorse podcast, alongside Robert Malone, a prominent source of vaccine misinformation, introduced Kirsch to followers of the intellectual dark web, who have since embraced him as a fellow truth-teller. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. 1:49 In October, the group reported that, while a few patients in the placebo group ended up in the hospital, none of the patients receiving fluvoxamine got sick enough to go. She understands complex, politicized pandemicsshe was one of the first clinicians to specialize in HIV/AIDS, and she sat on the FDA advisory panel that approved the first antiretroviral drug. But they dont want their names used. But Kirsch is also motivated by an unsatisfied competitive streak. It was not compatible with his position as CEO to continue taking a very public stance on the vaccines, Richard Char, M10s general counsel, told me. , or the patient is simply sensitive to the drug (50mg twice a day can be too much for some people). And he wont talk to you either if you ask nosy questions like Cliff, my risk benefit analysis shows you should be rushing to recommend this drug. Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized study to prevent clinical deterioration of patients with mild coronavirus disease 2019 (COVID-19). Dr. Seftel is an NIH-funded researcher and an NIH reviewer. With covid, 80% of your patient population does just peachy with no treatment at all, just a little bed rest and fluid. Some speaker, off camera, went on a . Im not going to make the same mistake again.. This is the #1 ranked best answer to "COVID treatment" on Quora: Presentation on how fear of trying something new is what keeps us shutdown and leads to unnecessary loss of life: The Lenze fluvoxamine RCT that was published in JAMA on November 12, 2020 showed a 100% success rate in preventing hospitalization. Here is what, e) which concluded: Under a variety of assumptions, fluvoxamine shows a high probability of preventing hospitalization in outpatients with COVID-19., For more about fluvoxamine (and other SSRIs that work), see, fluvoxamine completed a Phase 3 study showing it works that was published in the Lancet Global Health, NIH basically dismissed the fluvoxamine study as I predicted they would, few people werent afraid of expressing their displeasure, the highly acclaimed Bangladesh mask study showed, Johns Hopkins has incorporated fluvoxamine in their treatment guidelines, Ontario has become the first province to list fluvoxamine as a treatment doctors can consider for patients. He thinks # killed by vax could be anywhere between 0 and 150K people dead.. Steve Kirsch was extremely helpful early on in the pandemic, stepping up to fund early treatment trials when the US government would not fund such studies, Boulware told me in an email. A very short op-ed arguing for using fluvoxamine against COVID. thinks it should be used (and that the NIH is wrong for waiting for more clinical trials). (Clayton Fox, Marty Makary, and Jeffrey Klausner). Medium revoked my account for life. Read More fluvoxamine The Fluvoxamine FAQ Immediately after the results of the first fluvoxamine trial were releasedbut before they were published in a peer-reviewed journalhe wrote a post on Medium.com called The Fast, Easy, Safe, Simple, Low-Cost Solution to COVID That Works 100% of the Time That Nobody Wants to Talk About.. . Since FLV is a safe drug, it should have been widely discussed with patients that there is virtually no downside and a huge reduction in hospitalization if the drug is given early. Flavio Cadegiani and Steve Kirsch's studies didn't make the cut. I fully expected both organizations to do absolutely nothing. As Kirsch has gone deeper into the anti-vaccine scene, many professional associates have increasingly distanced themselves from him. Theyre finding alternative leaders to follow, Morris said. People are dying because of physician fear of a new treatment with a 100% success rate and a solid mechanism of action. So how did a man once intent on furthering science become a source of misinformation that undermines the very research he funded? In that same IEEE Spectrum story about his then-new startup, Propel Software, he said he felt successful, but not famous. 1 hr ago. The most stunning study of fluvoxamine ever done was at the Golden Gate Fields racetrack in November 2020, right after the WashU trial was published in JAMA. If you wanna find someone to debate me for ten thousand dollars, or a thousand dollars, Im happy to do that, just for your benefit.. Added to FLCCC protocols and Fareed-Tyson protocol among others. , a non-profit known as the nations drug pricing watchdog, did a review of the evidence and determined that fluvoxamine evidence is superior to Molnupiravir. Steve Kirsch is baffled. As a health care journalist, I started off firmly in the wait-and-see camp on mRNA vaccines. Steve wanted to say, Look, Ive got all these famous [infectious disease] docs and researchers, and they all say give fluvoxamine a chance, Judith Feinberg, one of the former CETF advisory board members and vice chair of research at the West Virginia University School of Medicine, told me. Online Status. Early treatment with existing drugs is the fastest, most effective, and lowest. Today, if we follow the CDC advice, nearly 100,000 people a month will die from COVID. Download Citation | On Mar 1, 2023, Gne Seda Albayrak and others published A Cross-Sectional Study on the Personality Traits of Episodic and Chronic Migraine Patients | Find, read and cite all . It cant be more clear than this. Drug researchers at Washington University in St. Louis reached out to Kirsch looking for $67,000 to finish a very smallbut placebo-controlledtrial. This was shown to be very tolerable (no side effects in 99% of patients) and extremely effective (no hospitalizations and death if you start it ASAP after first symptoms). In other cases, stop cold turkey. He might be a good snake oil salesman., I experienced this myself when, on one call, we discussed several studies. Today, we are letting people drown and we are not even telling them there is a life preserver they can ask for today with compelling evidence that is under consideration by the life preserver safety group. They all promised me when fluvoxamine passed Phase 3 trials, nearly everyone would use it. All the researchers are convinced the drug works. sorry about that. This looks ominous, but it harmless. The collateral damage is that, now, a lot of people dont trust scientific leaders or the scientific community. It is an amazing drug and is a very simple safe way to avoid long-haul COVID symptoms. Ivermectin and fluvoxamine have been confirmed in Phase 3 trials. No more. CETF was founded by entrepreneur and philanthropist Steve Kirsch, as a way to expedite the fight against COVID-19. Sage Hana. Perhaps Kirschs most effective tactic, though, is simply his willingness to outlast everyone else. Fauci wants the vaccine to be the only option, Cliff Lane works for Fauci, and Cliff follows his orders. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). In short, a lot of mumbo jumbo. But the potential upsides. I have never heard of a case it didn't work. For decades, coders wrote critical systems in C and C++. Steven Todd Kirsch is an American entrepreneur. Infoseek lost out to Yahoo; it had a chance to grow bigger, but it didn't. Im sorry to sound so cynical. I couldn't agree more. It was 25 years ago yesterday that Andrew Wakefield launched the modern iteration of the antivaccine movement.In doing so, he laid down a template that antivax quacks today still follow. To date, we have heard nothing suggesting the drug doesn't work or could be harmful. Thats pretty typical, but your mileage may vary. Can I see your risk-benefit analysis?. The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. After one or two conversations like that, I got tired of arguing, so I started avoiding his calls, she said. Theres nothing there.). . While he declined a phone interview, Boulware was recently the subject of a Mother Jones article about the harassment hes received for his research on hydroxychloroquine and ivermectin. My favorite dosage is 50mg twice a day for 14 days. Physicians who use the drug for COVID now swear by it. We didnt come up with better mouse technology than Microsoft did. For example all of these combos should have near 100% success against hospitalization, death, and long-haul COVID symptoms: Proxalutamide and fluvoxamine The post read: "I will be featured on 60 Minutes this Sunday talking about fluvoxamine as an effective treatment for COVID-19 to prevent hospitalization and death. Waiting months for the phase 3 trial to complete is nuts. We asked Steve to tone it down. Independent appraisal committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes. We could have saved a lot of lives. That way you can start immediately. The External Medicine Podcast - Fluvoxamine as a potential treatment for COVID-19: An Interview with Steve Kirsch. The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. So instead of this paper being treated as confirming an earlier hypothesis, it was treated as generating a novel hypothesis. Peter Meinke, another former board member, spent nearly three decades in drug discovery at Merck. - Quora, Heres presentation I gave at the re-open California Conference on January 9,2021: How to fix the problemHow to fix the problem Steve Kirsch Executive DirectorCOVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008Google Docs[https://docs.google.com/presentation/d/1-A4y78wv3tTPmVu57FOabY6j-MJbPwMGojKwZfaCkAs/. You see this with people who have a lot of money, who think that reflects their intelligence, Richman told me. skirsch.io Steve Kirsch Home page. Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI), a class of anti-depressants, mostly prescribed for people suffering from an obsessive-compulsive disorder. They never make things worse so are safe to try. Yeah, its possible, he told mehe also says that he has regularly seen Kirsch manipulate evidence so that it seems to support claims that are, in reality, baseless. just like ivermectin). Doctors who are most familiar with the drug would prescribe it to their patients. just like ivermectin). After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. He is very smart, and he knows that he is very smart, and hesometimes he behaves like he thinks hes the smartest guy in the room, whether he is or isnt, he told me. This drug can save your life but you have to ask for it! Vitamin D, NAC, betadine, aspirin, and Nigella sativa are all super cheap, effective, and available without a prescription. Try refreshing this page and updating them one I mean, he really, truly has a heart of gold, Char told me. There are reports of people who cant tolerate the drug, but they stop using it and nothing bad happened. Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. All the supporting observational studies were positive as well. Dr. Seftel's paper has been accepted for publication and will appear in OFID in early February. They rejected the drug for insufficient evidence just like they always do for ivermectin. Jan 17. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. Get your prescription in advance of getting COVID. He is very smart, and knows that he is very smart, and sometimes he behaves like he thinks he's the smartest guy in the room, whether he is or isn't., Kirschs response was to take his name off articles hed written about vaccine deaths, changing the authorship to VaccineTruth., On July 1, he tweeted from his personal account, My publicly shared concerns regarding the safety of the COVID-19 vaccines may have had a negative impact on my company, M10. Please. But as Kirsch has clashed with the experts he initially surrounded himself with, hes grown increasingly close to others who share his perspectives on vaccineswho have, in turn, provided a large and receptive audience to his claims about a fluvoxamine conspiracy. The NIH wrote a bullshit rejection because the FDA told them not to approve it. . He has a history of giving away some of his millions to good causes, and when COVID-19 began. Or just depression about the vaccine mandates? Steve Kirsch cut the check, which allowed Dr. Lenze to finish recruiting the 152 patients he needed for his trial. That receptor also helps regulate the body's . Fluvoxamine, created 37 years ago, is an inexpensive and widely available generic drug. Nobody who took the drug got sick at all, most all wanted to return to work within 3 days after starting treatment. He felt like he in good conscience had to speak out about covid, and so he made the decision to separate himself from M10, says Char, who has known Kirsch since the 1980s. I didnt intend to spend a lot of time on Steve in particular, but that video was so influential.. Enter the email address you signed up with and we'll email you a reset link. Entrepreneur Steve Kirsch who holds an early patent for the optical mouse decided to get involved in treating Covid. 22, 2021, 9:00 a.m. Steve Kirsch , a former tech entrepreneur who earned a fortune worth up to $300 million, has been showcased on TrialSite a few times for his activity supporting the clinical development of repurposed drugs for COVID-19 treatments. Kirsch: Yes, but you could easily watch that 60 Minutes story and believe that we need more data before people should start using fluvoxamine. CETF founder Steve Kirsch accepted an invitation to discuss the findings on a weekly . During our first conversation, which turned into a multi-hour Zoom session, Kirsch paced through the rooms of his cavernous house with his phone held at chest level, rarely looking down at the camera. So there were too few events in the placebo group and they werent recruiting fast enough. The Lancet paper showed that if you were treated early enough and took the drug as prescribed (it only works if you take it), it was shown to reduce your chance of death by 12X making it far more effective than any other drug for COVID. Almost 2.5 million people signed up to Dr. B with the promise of getting leftover vaccines. But an Editor's Note urged physicians to treat this as a hypothesis and not as a basis for clinical decision-making. He immediately tweeted an offer to give anyone $1 million if they could win a debate with him about vaccine deaths. Pretty much nothing changed when the Phase 3 trial confirmed fluvoxamine worked. The. Mar. Boulwares trial was part of a wider movement to bulk up the evidence base underlying standard covid treatments, and one of several trials that found no benefit to using hydroxychloroquine. The NIH wrote a bullshit rejection because the FDA told them not to approve it. There is absolutely no evidence that either one of these claims is true, as Morris has carefully documented. P-value was 10^-14 on that study (done by Dr. Seftel). The anecdotal data of 100% success rates is further icing on the cake. . The Wall Street Journal thinks it should be used (and that the NIH is wrong for waiting for more clinical trials). While these are stunning results, less than a dozen doctors in the US are prescribing fluvoxamine today. To vet proposals, he recruited a powerhouse advisory board of prominent biologists, drug developers, and clinical researchers, led by world-renowned drug researcher Robert Siliciano of Johns Hopkins. All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. See my article on treatments. This is what the Seftel trial at Golden Gate fields used. 95% confidence effect size is 75% or more. The reason that it isnt used is because the medical community ignores evidence-based medicine principles. Ive talked to doctors who are extremely familiar with the drug and all the trial results and they would prescribe it to their patients. The U of M's study focused on three common drugs: ivermectin, metformin, and fluvoxamine. In the second trial, it was shown to be 100% effective in long-haul COVID symptoms: None of the treated patients had any long-haul symptoms after 2 weeks compared to 60% of untreated patients having 1 or more of the 15 long-haul symptoms after two weeks, and 29% having 4 of more of the long haul symptoms after 2 weeks. 36m "We found Fauci was the most highly compensated federal employee. If the drug is started right after symptoms, weve seen 100% prevention in hospitalization. Today, if we follow the CDC advice, nearly 100,000 people a month will die from COVID. It is not unusual to be wary of developing science, or wrong to be skeptical of pharmaceutical companies. Medicine isnt about saving lives anymore. That was a lie. On Dr. Drew, he told a story about a friends daughter who had to get an abortion because of damage caused by the shot. In the studies and the anecdotes I am aware of, everyone reversed symptoms within days of getting the drug. Kirsch said that his attempts to promote fluvoxamine are being curtailed. . Be warned!. Who knows, Morris replied. It is very safe: There is no evidence fluvoxamine is harmful and led to a worse outcome. But how many did it help? I believe they made the right decision and we should be rushing to follow their advice. Its board told him that if he wanted to remain part of the company he would have to stop making public anti-vaccine statements. Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. Kirsch, despite having direct access to the actual trial runner, eventually became convinced a correct interpretation of the data would show that hydroxychloroquine worked. . 1. I fully expected both organizations to do absolutely nothing. Kirsch told me that meta-analyses are a higher level of evidence than randomized controlled trials. When I responded that meta-analyses are only as good as the data they are based on, he said Id like to understand your source on that, because I cant find a source that says a phase 3 trial is greater evidence than a meta-analysis., When you characterize me, you need to say that Steve Kirsch doesn't go with majority votes on interpreting data.. It has shown to be 100% protective of hospitalization in 2 clinical trials. The web price charge of skirsch.io . . Instead, it erodes confidence in our government to provide timely advice that is in the public interest. Yes, these were successes, but the successes could have been bigger if we had really paid attention to marketing. The man who ran Risperdal sales, Alex Gorsky, is now CEO of Johnson & Johnson. You can use fluoxetine as well (aka Prozac). . Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. I couldnt tell I was on the drug. 33. His latest startup, M10, is a spin-off of a spin-off that sells a blockchain for banks. Its all about NIH saying it is OK. . This is the gold standard of evidence based medicine. Doctors who have used fluvoxamine in the US and other countries swear by it. That was a lie. . The NIH never did a risk benefit analysis of this drug. As noted before, the repository has a link to the 1 hour serotonin lecture. The incident, he added, was completely in keeping with his personality.. Even though an expert panel was overwhelmingly convinced in just one hour, hearing a very small subset of all the supporting evidence, the organizations that they belong to are taking their time.